Featured Articles

Herbal Therapy Is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth

Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the concentration of bacteria of more than 100 000 colony-forming units per mL of proximal jejunal fluid. Although the overall prevalence of SIBO in the general public is unknown, a metaanalysis has shown that the prevalence of SIBO is approximately 56% among patients with irritable bowel syndrome (IBS). At present, the prevalence of SIBO in the community or in a tertiary-care gastroenterology referral practice remains unknown. SIBO is becoming an increasingly significant problem in clinical practice as its manifestations can be protean and range from a full-blown enteropathy causing profound malabsorption and malnutrition simulating celiac disease to mild symptoms that overlap with IBS. There are several factors involved in the pathogenesis of SIBO that have in common a disruption in the natural protective antibacterial mechanisms of the gut as shown in Tables 113. These factors, alone or in combination, can predispose the gut toward dysbiosis and favor the growth and colonization of aerobes and anaerobes in the proximal jejunum and may provide barrier(s) from achieving durable remission of symptoms following treatment.Currently, lactulose breath testing (LBT) is the most commonly used procedure for diagnosing SIBO.,LBT is useful as an indirect testing method for SIBO, given that the human gastrointestinal (GI) tract does not absorb or use lactulose, which is metabolized by bacteria to produce hydrogen and methane gas. These gases are then measured by gas chromatography. Once suspected SIBO is diagnosed, it should be treated to prevent its myriad of adverse consequences.

The effect of Astragalus Polysaccharide 

on the Epstein-Barr virus lytic cycle

Effects of a polysacharide from Chinese herbal plant Astragalus membranaceus (APS) on the expression of Epstein-Barr virus (EBV) immediate early proteins Zta, Rta and EA-D in Raji cells were examined. EBV switch from latent to lytic cycle in Raji cells was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and sorbol butyrate (SB) and the effects of APS were examined by immunofluorescence, western blotting and flow cytometry. APS in a non-cytotoxic concentration of 30 μg/ml significantly suppressed the expression of Zta, Rta and EA-D during the EBV lytic cycle. Our observations indicate that APS is potentially useful as an anti-EBV drug.

Role of Thiols in Oxidative Stress

A well-regulated redox state is essential for normal physiological function and cellular metabolism. In most eukaryotic cells, protein cysteine thiols are most sensitive to fluctuations in the cellular redox state. Under normal physiological conditions, the cytosol has a highly reducing environment, which is due to high levels of reduced glutathione and complex system of redox enzymes that maintain glutathione in the reduced state. The reducing environment of the cytosol maintains most protein thiols in the reduced state; although some non-exposed cysteine could be present as disulfides. Upon physiological increase in cellular oxidants, such as due to growth factors, cytokines and thiol-disulfide exchange reactions, specific proteins could act as redox switches that regulate the conformation and activity of different proteins. This reversible post translational modification enables redox-sensitive dynamic changes in cell signaling and function. Physiological oxidative stress could lead to the formation of sulfenic acids, which are usually intermediate states of thiol oxidation that are converted to higher order oxidation states, intramolecular disulfides or mixed disulfides with glutathione. Such glutathiolation reactions have been found to regulate the function of several proteins involved in intracellular metabolism, signal transduction and cell structure. Excessive oxidative stress results in indiscriminate and irreversible oxidation of protein thiols, depletion of glutathione and cell death. Further elucidation of the relationship between changes in cell redox and thiol reactivity could provide a better understanding of how redox changes regulate cell function and how disruption of these relationships lead to tissue injury and dysfunction and the development of chronic diseases such as cancer and cardiovascular disease.

Featured Videos

Nutrition Is The Future

Biogenetix CEO Dr. Eric Huntington gives a detailed talk about nutrition. He covers the main causes of death in America today and the nutritional factor connecting them together including the top offender, Sugar. By just regulating this one factor you could change your entire life. 

From raw sugar to wheat, see how every aspect of your health is touched by the culprit. Heart disease, cancer, and more all find their roots in the sugar society we currently live in. Learn how reducing our dependence on sugar can save our lives. We truly are what we eat!

 

Fighting The Opioid Epidemic

Dr. Brad Watts discusses how practitioners can support patients battling Neuropathic Pain. With the Opioid epidemic on pace to cause over a half million deaths in the next decade finding ways to manage pain without addictive treatments have become a must for optimizing therapy. Dr. Watts covers why Opioids have taken such a commanding role in pain management. 

Get to the bottom of how to provide high-quality pain support without incorporating addictive treatments that cause more problems than they solve with this informative video. Learn how Biogenetix’ Pain Support Kit can play a key role in your patient’s treatment program. 

Escalate Regenerative Therapy

Dr. Brad Watts discusses how to get the most out of your patients’ Regenerative Therapy. Creating an optimal outcome for patients is the key to any therapy treatment. Dr. Watts covers the many points needed to establish an environment to support success. 

Help your patients achieve their desired results by managing & controlling inflammation through the entire process. Dr. Watts goes into detail about the myriad of ways you can address inflammation during therapy to ensure that treatments take hold. By following this path laid out, you can maximize your patients regenerative therapy from beginning to end.

Featured Webinars

Next Generation Neuro Support

Dr. Brad Watts hosts an enthralling webinar covering Next Generation Neuro Support. Learn about how the threat of Alzheimer’s & Cognitive Disorder have been wreaking havoc on the Baby Boomers. By looking at the lifestyle challenges facing patients, Dr. Watts covers what heightens the risks & how to reduce those risks even in patients deemed genetically prone.

Supporting Regenerative Pathways

Dr. Brad Watts has provided this informative webinar on supporting regenerative pathways and how to incorporate the Regenerative Kit into your patient’s treatment. This kit goes hand in hand with Regenerative Therapy programs. Learn about the role inflammation plays, the history behind the science for incorporating nutrition into recovery and how with the assistance of the Regenerative Kit you can enhance your patient experience.

Join the webinar below to find out what has everyone buzzing!

Integrating With Vitamin D

Listen to Dr. Brad Watts as he lays out the background information on Vit D therapeutic intervention, including who needs it, who gets it, and which formulations to use with which patients. This short 30 min webinar gives you the details you need and a plan to support your patients and family.

  • Of your bodies roughly 30,000 genes vitamin D affects 10% of them.
  • Vitamin D exhibits infection fighting abilities.
  • Low vitamin D levels are linked to increase risk of cognitive decline.

Vitamin D therapeutic intervention, is a great thing to learn about by joining the webinar below!

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