Featured Articles

NF-κB Signaling In Inflammation

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.

Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults

We aimed to investigate the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time. The study population (n = 2,596) was derived from a population-based longitudinal study on ≥60-year-olds living in Stockholm. Participants were clinically assessed at baseline, 3- and 6-year follow-ups. Multimorbidity was measured as the number of chronic conditions from a previously built list of 60 diseases. Linear mixed models were applied to analyze the association between baseline tGSH levels and the rate of multimorbidity development over 6 years. We found that at baseline, participants with ≥4 diseases had lower tGSH levels than participants with no chronic conditions (3.3 vs 3.6 µmol/L; p < .001). At follow-up, baseline levels of tGSH were inversely associated with the rate of multimorbidity development (β * time: −0.044, p < .001) after adjusting for age, sex, education, levels of serum creatinine, C-reactive protein, albumin, body mass index, smoking, and time of dropout or death. In conclusion, serum levels of tGSH are inversely associated with multimorbidity development; the association exists above and beyond the link between tGSH and specific chronic conditions. Our findings support the hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity.

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview

Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Thus, randomised controlled clinical trials have shown supplementation with CoQ10 or CoQ10 plus selenium reduces mortality by approximately 50% in patients with cardiovascular disease, or in the normal elderly population, respectively. Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease. The beneficial role of supplemental CoQ10 in the above disorders is considered to result from a combination of its roles in cellular energy generation, as an antioxidant and as an anti-inflammatory agent.

Featured Videos

Solving Systemic Inflammation

Systemic Inflammation can toss any treatment plan into chaos. Clouding the bodies localized inflammation needed to rectify a problem.

Using Kapp-X can calm systemic inflammation allowing your body to properly process your NFkB responses. This means your patients can finally begin addressing the conditions causing their problems instead of the systemic inflammation clogging the internal pathways.

Dr. Brad Watts gives an in-depth 5 min look at how this exact problem arises and how you can confront it head on with the help of Kapp-X.

Fighting The Opioid Epidemic

Dr. Brad Watts discusses how practitioners can support patients battling Neuropathic Pain. With the Opioid epidemic on pace to cause over a half million deaths in the next decade finding ways to manage pain without addictive treatments have become a must for optimizing therapy. Dr. Watts covers why Opioids have taken such a commanding role in pain management. 

Get to the bottom of how to provide high-quality pain support without incorporating addictive treatments that cause more problems than they solve with this informative video. Learn how Biogenetix’ Pain Support Kit can play a key role in your patient’s treatment program. 

Escalate Regenerative Therapy

Dr. Brad Watts discusses how to get the most out of your patients’ Regenerative Therapy. Creating an optimal outcome for patients is the key to any therapy treatment. Dr. Watts covers the many points needed to establish an environment to support success. 

Help your patients achieve their desired results by managing & controlling inflammation through the entire process. Dr. Watts goes into detail about the myriad of ways you can address inflammation during therapy to ensure that treatments take hold. By following this path laid out, you can maximize your patients regenerative therapy from beginning to end.

Featured Webinars

Next Generation Neuro Support

Dr. Brad Watts hosts an enthralling webinar covering Next Generation Neuro Support. Learn about how the threat of Alzheimer’s & Cognitive Disorder have been wreaking havoc on the Baby Boomers. By looking at the lifestyle challenges facing patients, Dr. Watts covers what heightens the risks & how to reduce those risks even in patients deemed genetically prone.

Supporting Regenerative Pathways

Dr. Brad Watts has provided this informative webinar on supporting regenerative pathways and how to incorporate the Regenerative Kit into your patient’s treatment. This kit goes hand in hand with Regenerative Therapy programs. Learn about the role inflammation plays, the history behind the science for incorporating nutrition into recovery and how with the assistance of the Regenerative Kit you can enhance your patient experience.

Join the webinar below to find out what has everyone buzzing!

Integrating With Vitamin D

Listen to Dr. Brad Watts as he lays out the background information on Vit D therapeutic intervention, including who needs it, who gets it, and which formulations to use with which patients. This short 30 min webinar gives you the details you need and a plan to support your patients and family.

  • Of your bodies roughly 30,000 genes vitamin D affects 10% of them.
  • Vitamin D exhibits infection fighting abilities.
  • Low vitamin D levels are linked to increase risk of cognitive decline.

Vitamin D therapeutic intervention, is a great thing to learn about by joining the webinar below!

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